Description

What Ibutamoren's Effects?

In the body, MK-677 binds to ghrelin receptors on the surfaces of cells. This triggers a series of chain reactions including increased secretion of several hormones such as growth hormone (GH) and insulin-like growth factor (IGF-1).
These chain reactions are normally triggered by the action of ghrelin, a peptide hormone primarily released by endocrine cells in the intestines and stomach (1). Ghrelin has various physiological effects such as regulation of appetite (2) and adipose tissue (3), as well as of carbohydrate and energy metabolism (4). Recent studies have also demonstrated its role in cognitive function (5-6).
By mimicking ghrelin, MK-677 thus produces significant physiological benefits:
• it boosts muscle growth and strength, by increasing lean body mass (bigger muscles, increased muscle mass, prevention of loss of muscle during weight loss, etc) (7-10), without adding fat mass.
• it combats the muscle-wasting typically seen in older people or those temporarily incapacitated (with hip fractures, for example (11).
• it boosts bone density and renewal (by increasing levels of osteocalcin) (12).
• it improves sleep quality and duration (13). The rises in levels of certain hormones (in particular growth hormone and prolactin) appear to increase the duration of stage 4 sleep (the deepest of the sleep cycle) as well as that of rapid eye movement (REM), part of paradoxical sleep (14).
• it combats cellular ageing, primarily by compensating for decreased levels of growth hormone.
• it has potential nootropic effects
• it promotes faster wound-healing and recovery (15-16) as well as increased tolerance to exercise (17-18).
• it increases lipolysis (fat breakdown) (19).
• it reduces nitrogenous waste (20).
• it lowers blood levels of LDL-cholesterol.

These potential effects are the result of Ibutamoren's principal action of directly increasing circulating levels of IGF-1, a peptide hormone responsible for boosting protein synthesis and promoting overall tissue growth.

Clinical trials are continuing in order to identify any potential side effects, with a view to potentially authorising its sale for human consumption. Studies conducted so far have demonstrated slight increases in blood pressure, glycated haemoglobin and appetite (21). They have also shown that were it to be authorised for human consumption, it would be contraindicated for those with a history of congestive heart failure, especially elderly individuals. In any case, monitoring blood parameters would be essential, and it would only be possible to recommend those products with rigorously-controlled purity.

Who Might Benefit From Ibutamoren?

Currently, Ibutamoren is still at the stage of pre-clinical testing. It is therefore available solely for research purposes and is not approved for human consumption. However, its physiological effects and therapeutic potential mean that certain groups of people may be interested in monitoring developments in its research:
• those seeking improved sports performance and greater tolerance to exercise.
• those looking to boost their muscle mass and strength
• those recovering from physical injury
• those deficient in growth hormone
• those who've suffered muscle wasting or bone loss
• those who want to slow down the ageing process.

How Does It Differ From Anabolic Steroids?

Like MK-677, anabolic steroids produce an increase in muscle mass and physical strength, but that's where the similarity ends. Anabolic steroids are fatty acids which bind to 'androgen receptors' and trigger the expression of a number of target genes. This interaction causes anabolic effects, as well as a number of unintended consequences, such as a significant increase in virilisation (hairiness, growth in vocal cords, increased risk of baldness), a halt in natural production of sex hormones, an increase in LDL cholesterol, a rise in blood pressure and the development of problematic structural changes in heart ventricles. These unwelcome effects are damaging to the bodybuilding enthusiasts and elite athletes who use them.

Scientific studies show that MK-677 does not cause any side-effects. Depending on the results of the latest clinical trials, it could, in the years to come, constitute a safer alternative to anabolic steroids and a more effective one than growth hormone-releasing peptides (GHRPs), the bioavailability and half-life of which remain very low.

Ibutamoren thus appears to be an innovative and credible alternative for stimulating growth hormone secretion. It is already benefiting from sound clinical trials and produces far fewer side-effects than the substances it closely resembles, such as anabolic steroids and GHRPs.

Note: This product is for research purposes only. It is not approved for human consumption.

Written: October 2018.

References
1. Ariyasu, H.; Takaya, K.; Tagami, T.; Ogawa, Y.; Hosoda, K.; Akamizu, T.; Suda, M.; Koh, T.; Natsui, K.; Toyooka, S.; et al. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J. Clin. Endocrinol. Metab. 2001, 86, 4753-4758.

2. Bowers CY, Momany F, Reynolds GA, et al. Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro. Endocrinology 1980; 106:663-667.

3. Bowers CY, Momany FA, Reynolds GA, et al. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 1984;114:1537-1545.

4. Bowers CY. History to the discovery of ghrelin. Methods Enzymol 2012;514:3-32.

5. Gahete, M.D.; Cordoba-Chacon, J.; Kineman, R.D.; Luque, R.M.; Castano, J.P. Role of ghrelin system in neuroprotection and cognitive functions: Implications in Alzheimer's disease. Peptides 2011, 32, 2225-2228.

6. Kim, C.; Kim, S.; Park, S. Neurogenic Effects of Ghrelin on the Hippocampus. Int. J. Mol. Sci. 2017, 18.

7. Binnerts A, Swart GR, Wilson JH, et al. The effect of growth hormone administration
in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clin Endocrinol 1992;37:79-87.

8. Snel YE, Doerga ME, Brummer RJ, et al. Resting metabolic rate, body composition and related hormonal parameters in growth hormone-deficient adults before and after growth hormone replacement therapy. Eur J Endocrinol 1995; 133:445-450.

9. Nass R, Pezzoli SS, Oliveri MC, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med 2008; 149:601-611.

10. Svensson J, Lonn L, Jansson JO, et al. Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. J Clin Endocrinol Metab 1998; 83:362-369.

11. Svensson J, Lonn L, Jansson JO, et al. Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. J Clin Endocrinol Metab 1998; 83:362-369.

12. Murphy MG, Bach MA, Plotkin D, et al. Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group. J Bone Min Res 1999; 14:1182-1188.

13. Copinschi G, Leproult R, Van Onderbergen A, et al. Prolonged oral treatment with MK- 677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology 1997;66:278-286.

14. Copinschi G, Leproult R, Van Onderbergen A, et al. Prolonged oral treatment with MK- 677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology 1997;66:278-286.

15. Bach MA, Rockwood K, Zetterberg C, et al. The effects of MK0677, an oral growth hormone secretagogue, in patients with hip fracture. J Am Geriatr Soc 2004;52:516-
523.

16. Adunsky A, Chandler J, Heyden N, et al. MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study. Arch Gerontol Geriatr 2011;53:183-189.

17. Jorgensen JO, Pedersen SA, Thuesen L, et al. Long-term growth hormone treatment in growth hormone deficient adults. Acta Endocinol 1991;125:449-453.

18. Whitehead HM, Boreham C, Mcllrath EM, et al. Growth hormone treatment of adults with growth hormone deficiency: results of a 13-month placebo controlled cross- over study. Clin Endocrinol 1992;36:45-52.

19. Melmed S. Physiology of growth hormone. In: Rose BD, ed. UpToDate; 2008; Waltham, MA.

20. Murphy MG, Plunkett LM, Gertz BJ, et al. MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. J Clin Endocrinol Metab 1998;83:320-325.

21. Sevigny JJ, Ryan JM, van Dyck CH, et al. Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial. Neurology 2008;71:1702-1708.

What Is LGD 4033?

LGD 4033, also known as Ligandrol is a Selective Androgen Receptor Modulator (SARM). It was developed by a San Diego based company, Ligand Pharmaceuticals. It is currently under research at Viking Therapeutics.

It connects to the androgen receptors in the muscles and bones inside your body selectively. It is known to benefit in curing muscle wasting and bone diseases. It can also help in building lean muscle mass and inhibiting muscle loss.

They are also considered a safer option than steroids. It is believed that they don't affect other organs in the body, unlike steroids. Also known as Anabolicum, it has become the preferred performance enhancer of many fitness enthusiasts and bodybuilders.

SARMS only became popular because there were concerns regarding the effects of steroids. They are known for minimal side effects that can be reversed with regular PCT.

What Is LGD 4033?

LGD 4033, also known as Ligandrol is a Selective Androgen Receptor Modulator (SARM). It was developed by a San Diego based company, Ligand Pharmaceuticals. It is currently under research at Viking Therapeutics.

It connects to the androgen receptors in the muscles and bones inside your body selectively. It is known to benefit in curing muscle wasting and bone diseases. It can also help in building lean muscle mass and inhibiting muscle loss.

They are also considered a safer option than steroids. It is believed that they don't affect other organs in the body, unlike steroids. Also known as Anabolicum, it has become the preferred performance enhancer of many fitness enthusiasts and bodybuilders. SARMS only became popular because there were concerns regarding the effects of steroids. They are known for minimal side effects that can be reversed with regular PCT.

Benefits Of LGD 4033

This new SARM has definitely garnered a lot of attention in the medical world. LGD 4033 has some noteworthy benefits that we will be discussing here. Read on to know about them!

• Lean Muscle Mass gain:

This is one of the main benefits of Ligandrol. It targets the androgen receptors in bones and muscles and starts the process of muscle regeneration. Even the lowest dosages can help you gain considerably. It burns down the body fat and gives you sharper and shredded muscles.
One can expect to gain about 4 to 6 kgs of muscle mass in one cycle of Ligandrol. This muscle mass later helps you in getting that muscular body after cutting and shredding.

• Increased Strength:

With great muscles, there is an inflow of strength in your body. You get more energy to work out effectively. You can lift heavier weights in the gym without any strain in your body.
Ligandrol also helps in increasing the strength which is crucial for the workouts. You experience considerable strength gain with this SARM. But do not forget to take a protein-rich diet that will help you replenish the lost energy.

• Maintain Muscle Mass:

Once you gain the desired muscle mass, it is important to maintain it as well. LGD 4033 can help you sustain this mass as well during a caloric deficit. This deficit is formed when your calorie intake is less than what you are burning. This is done because you need to lower your calorie intake in the cutting phase.
After you gain the mass, it's time to get that shredded look. Ligandrol ensures that you only experience the burning of fat during this phase. It prevents muscle loss and maintains them.

• Enhanced Recovery:

After those long hours in the gym and training hard, your muscles can undergo serious wear and tear. The muscle fibers tear during this and rebuild themselves. This rebuilding makes them much stronger and thus adding to your body strength.
LGD 4033 ensures the speedy recovery of those muscles. With this, you can get back to training in no time. As the recovery is faster, you can save yourself from all the serious injuries during the workout session.

How To Take LGD 4033 (Dosage)

For bulking: To increase muscle size and strength, take up to 30mg per day for 8-12 weeks.

For cutting: To shred body fat without muscle loss, take up to 15mg per day for 8-12 weeks.

For recomposition: To gain lean muscle mass along with losing bodyweight, take up to 15mg per day for 8-12 weeks.

LGD4033 has a half-life of around 24-36 hours. It means half of it will stay in your system after 24 hours. This means you have to take it once in a day or split into two doses morning and night.

LGD 4033 Reviews: What People Say Before And After?

The SARM only works when combined with a good diet and exercise. It's a fact that most of us are aware of it. These are the two prerequisites of consuming LGD4033. You cannot expect results without these too.

Many gym enthusiasts found it more reliable than the usual steroids. One can expect to gain about 5-10 pounds of lean muscle mass with this SARM. Your body fats get burned up and muscles take their place. You will become leaner with pronounced stomach muscles.

It allows minimal bloating in the stomach and the gains are clean. Many consumers claim a considerable increase in strength.

LGD 4033 Cycle

The cycle generally runs from 6 to 8 weeks. You need to take it a minimum for 6 weeks, only then it is worth it. In each cycle, you need to take on 5-30mg of the LGD 4033. Do not increase the amount even if you extend the cycle.

Also, needless to say, but you have to be very patient. You can't expect results in one or two weeks. It takes its own time to kick in and show results.

If you are an experienced user, you can increase the cycle with a moderate amount of SARM. A cycle of 8 to 12 weeks is recommended for you. Don't rush into it to get faster results. It won't help and you will only end up harming yourself.
You might have to use PCT after the SARM cycles. After this, 2-3 weeks of rest is necessary. You might feel that you are wasting time which could be used to start a new cycle.

But trust us, this is vital for you to rejuvenate and get back with replenished strength. This period refreshes you and makes you ready for the next cycle.

Side Effects Of LGD 4033

LGD4033 is still a research chemical. Therefore, it should be used in moderation. SARMs have very few side effects if they are used in proper amounts.

The most common side effects are nausea, headaches, water retention, and fatigue. It can also lead to testosterone suppression which is one of the major side effects. Testosterone is crucial for males to gain muscle strength.

Increase your water intake if you feel such symptoms, it can help you get some temporary relief. These side effects are very rare and most people don't even experience them. If you stop the use immediately and go for PCT, the side effects go away. PCT stands for Post Cycle Therapy that you can take after the SARM cycle. These are a bunch of supplements that help you fight the side effects. A couple of weeks rest after the PCT will help you recover fine. You can easily order these therapy supplements online.

Most people don't know about PCT and therefore don't use it. If you don't use PCT supplements, your body takes a longer time to recover.

During this time you lose all your gains and all your hard work goes to waste.

If you think your symptoms are getting out of hand, go for it. You can start with the mild PCT or anti-estrogen to relieve the symptoms.
Then, there is the Red PCT which is made from all-natural seed extracts. Go for the one that suits you the best.